Chloride → Salicyloyl chloride

HRID 1416431Notes

Reaction equation

HRID 1416431 reaction equation
[C:1]([OH:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[Cl-:11]>N1C=CC=CC=1>[C:1]([Cl:11])(=[O:10])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4]

Participants

4

Reactant 2

HCID 312ChlorideHCID 338Salicylic Acid

Product 1

HCID 74041Salicyloyl chloride

Reagents, catalysts & solvents 1

HCID 1049PyridineCatalyst

Procedure

In the first step, salicylic acid is mixed with thionyl (or oxalyl) halide, most preferably chloride, (molar ratio in the general range of from 1:1 to 2:1) in an anhydrous, typically non-polar, solvent, in the presence of pyridine catalyst, at a temperature of from 20 to 45° C. for 0.5-2 hours. At the end of this reaction, salicylic acid chloride is obtained. Optionally, the solvent is distilled at least partially.

Workup

  1. customAt the end of this reaction

Sources & evidence

ORD record
ord-365bb550ba2f4ee19658451836c12236
Source dataset
uspto-grants-1999_06
Patent number
US05912380

Reaction notes

Loading…