Acetyl chloride → HCID 70153691, compound

HRID 1416652Notes

Reaction equation

HRID 1416652 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N:11][CH:12]=[C:13]([NH2:15])[CH:14]=1.[C:16]([Cl:19])(=[O:18])[CH3:17]>C1COCC1>[ClH:19].[ClH:19].[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N:11][CH:12]=[C:13]([NH:15][C:16](=[O:18])[CH3:17])[CH:14]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 21309646HCID 21309646, compound

Product 1

HCID 70153691HCID 70153691, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5-amino-pyridine from Example 94 is dissolved in THF and reacted with acetyl chloride according to standard procedures. The product is purified by chromatography on silica gel and converted into the title compound by treatment with HCl in ether according to Example 14c.

Workup

  1. customThe product is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-8768a8e9c40642be8af6d93d011815e3
Source dataset
uspto-grants-1999_06
Patent number
US05914328

Reaction notes

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