反应详情

温度

90 °C

To a solution of 25.8 g (99.2 mMol) of 1-(4-fluorophenyl)-2-(4-methylthiophenyl)ethan-1-one from Step 3 in 200 ml of dimethylformamide was added 33 ml (30 g, 250 mMol) of dimethylformamide dimethyl acetal. The resulting mixture was stirred at 90° C. for 2 hours. Evaporation of the volatiles gave 1-(N,N-dimethylamino)-1-(4-fluorophenyl)-2-(4-methylthiophenyl)prop-1-en-3-one as a yellow solid (32.5 g).

1. customEvaporation of the volatiles