反应详情

温度

75 °C

To a 500 ml 2-necked flask fitted with a thermometer and magnetic stirrer was added 20 g (76.9 mMol) of 1-(4-fluorophenyl)-2-(4-(methylthio)phenyl)ethan-1-one, Example 1, Step 3, 18.3 g (154 mMol) of dimethylformamide dimethyl acetal and 50 ml dry dimethylformamide (DMF). The reaction mixture was heated to 75° C. for 3 hours, cooled to room temperature and evaporated to dryness and to recover 26.1 g a yellowish orange solid.

1. customTo a 500 ml 2-necked flask fitted with a thermometer and magnetic stirrer
2. temperaturecooled to room temperature
3. customevaporated to dryness
4. customto recover 26.1 g a yellowish orange solid