Dimethyl Sulfate → HCID 22742521, compound

HRID 1417041Notes

Reaction equation

HRID 1417041 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]([N+]([O-])=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.COS(OC)(=O)=O>CN(C=O)C>[CH3:5][NH3+:6].[CH:7]1[C:8]2[C:3](=[CH:2][CH:11]=[CH:10][CH:9]=2)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 8169835-Bromo-8-nitroisoquinoline

Product 1

HCID 22742521HCID 22742521, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 5-bromo-8-nitroisoquinoline (0.99 g, 3.91 mmol) and dimethylsulfate (0.41 mL) in anhydrous DMF (20 mL) was heated at 80° C. for 24 hours. After removing the DMF in vacuo, the isoquinoiine methylammonium salt was obtained (used without further purification).

Workup

  1. customAfter removing the DMF in vacuo

Sources & evidence

ORD record
ord-ee9db5ca18834a379c51cbb1607cc2b6
Source dataset
uspto-grants-1999_06
Patent number
US05917053

Reaction notes

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