HCID 14025391, compound → HCID 54434705, compound

HRID 1417109Notes

Reaction equation

HRID 1417109 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([O:14][CH3:15])[C:5]([N+:11]([O-])=O)=[C:6]([CH2:8][C:9]#[N:10])[CH:7]=1>C1COCC1.[Zn]>[NH2:11][C:5]1[C:4]([O:14][CH3:15])=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=1[CH2:8][C:9]#[N:10]

Participants

4

Reactant 1

HCID 14025391HCID 14025391, compound

Product 1

HCID 54434705HCID 54434705, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 8028TetrahydrofuranSolvent

Procedure

In accordance with Example No. 3, 22.7 g of (5-chloro-3-methoxy-2-nitrophenyl)acetonitrile dissolved in a 100 ml/70 ml mixture of THF/37% HCl were reduced with 26 g of zinc powder. 19 g of (2-amino-5-chloro-3-methoxyphenyl)acetonitrile were obtained (yield=97%).

Sources & evidence

ORD record
ord-f27001886a504a48bfbdab24b4c12a20
Source dataset
uspto-grants-1999_03
Patent number
US05876465

Reaction notes

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