Sodium hydride → HCID 70346516, compound

HRID 1417159Notes

Reaction equation

HRID 1417159 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([C:11]2([OH:26])[C:15]3=[N:16][CH:17]=[CH:18][C:19]([C:20]4[S:21][CH:22]=[CH:23][CH:24]=4)=[C:14]3[C:13](=[O:25])[O:12]2)[N:4]=1.[H-].[Na+:28]>C1C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([C:11]([C:15]2[N:16]=[CH:17][CH:18]=[C:19]([C:20]3[S:21][CH:22]=[CH:23][CH:24]=3)[C:14]=2[C:13]([O-:25])=[O:12])=[O:26])[N:6]=1.[Na+:28]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 70345229HCID 70345229, compound

Product 1

HCID 70346516HCID 70346516, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

0.4 g of 7-(4,6-dimethoxypyrimidin-2-yl)-4-(2-thienyl)-7-hydroxyfuro[3,4-b]pyridin-5(7H)one was dissolved in 100 ml of benzene, and 0.05 g of 60% sodium hydride was added thereto under cooling with ice. Then the resulting mixture was stirred at room temperature for one day, and the precipitated crystals were sufficiently washed with benzene to obtain 0.4 g (yield 97%) of the desired compound. m.p.: >300° C.

Workup

  1. temperatureunder cooling with ice
  2. washthe precipitated crystals were sufficiently washed with benzene

Sources & evidence

ORD record
ord-4f4eabcc328044b5af088dba95e88d41
Source dataset
uspto-grants-1999_03
Patent number
US05877120

Reaction notes

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