Sodium hydride → HCID 70346448, compound

HRID 1417162Notes

Reaction equation

HRID 1417162 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([C:11]2([OH:28])[C:15]3=[N:16][CH:17]=[CH:18][C:19]([C:20]4[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=4)=[C:14]3[C:13](=[O:27])[O:12]2)[N:4]=1.[H-].[Na+:30]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([C:11]([C:15]2[N:16]=[CH:17][CH:18]=[C:19]([C:20]3[CH:21]=[CH:22][C:23]([Cl:26])=[CH:24][CH:25]=3)[C:14]=2[C:13]([O-:27])=[O:12])=[O:28])[N:4]=1.[Na+:30]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 70346016HCID 70346016, compound

Product 1

HCID 70346448HCID 70346448, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.4 g of 7-(4,6-dimethoxypyrimidin-2-yl)-4-(4-chlorophenyl)-7-hydroxyfuro[3,4-b]pyridin-5-(7H)one was dissolved in 100 m of toluene, and 0.05 g of 60% sodium hydride was added thereto. The mixture was stirred at room temperature for one day. The precipitated crystals were collected by filtration and sufficiently washed with acetone to obtain 0.25 g (yield 60%) of the desired compound. m.p.: 263°-267° C.

Workup

  1. additionwas added
  2. filtrationThe precipitated crystals were collected by filtration
  3. washsufficiently washed with acetone

Sources & evidence

ORD record
ord-a6b29f474b194a9ea3f72fad3ad2df3b
Source dataset
uspto-grants-1999_03
Patent number
US05877120

Reaction notes

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