Methane → 4-Amino-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide

HRID 1417275노트

반응식

HRID 1417275 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:11]=[C:12]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([NH:25]C(=O)C)=[CH:21][CH:20]=3)(=[O:18])=[O:17])[S:13][CH:14]=2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[OH-].[Na+].C>Cl>[NH2:25][C:22]1[CH:23]=[CH:24][C:19]([S:16]([NH:15][C:12]2[S:13][CH:14]=[C:10]([C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)[N:11]=2)(=[O:18])=[O:17])=[CH:20][CH:21]=1

참가 물질

5

반응물 3

HCID 297MethaneHCID 14798Sodium HydroxideHCID 21845562N-{4-[4-(3-Nitro-phenyl)-thiazol-2-ylsulphamoyl]-phenyl}-acetamide

생성물 1

HCID 104071774-Amino-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide수율 37.8%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

0.47 g of N-{4-[4-(3-nitro-phenyl)-thiazol-2-yl-sulphamoyl]-phenyl}-acetamide was suspended in 10 ml of 6N hydrochloric acid and heated to boiling overnight. The cooled mixture was treated with 35 ml of 2N sodium hydroxide solution. After the addition of 0.4 g of active charcoal the mixture was stirred at room temperature for 30 minutes and subsequently the active charcoal was filtered off. The product separated upon neutralization with concentrated hydrochloric acid. Recrystallization from 50 ml of 40% ethanol yielded 0.16 g of 4-amino-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide as yellowish crystals.

후처리

  1. temperatureheated
  2. filtrationsubsequently the active charcoal was filtered off
  3. customThe product separated upon neutralization with concentrated hydrochloric acid
  4. customRecrystallization from 50 ml of 40% ethanol

출처 및 근거

ORD 기록
ord-8c105f2bde67485990acabdceb6d7477
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877193

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