HRID1417441

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：Cc1c(C(=O)N[C@H](C(=O)NC(CC(=O)OC(C)(C)C)C(=O)COCc2c(Cl)cccc2Cl)C(C)C)n(C)c2ccccc12

HCID86584003

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)N[C@H](C(=O)NC(CC(=O)O)C(=O)COCc2c(Cl)cccc2Cl)C(C)C)n(C)c2ccccc12

HCID22942386

未命名化合物

收率 76.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID7519

Anisole

C7H8O

PROCEDURE

实验过程

A solution of N-[(1,3-Dimethylindole-2-carbonyl)valinyl]-3-amino-4-oxo-5-(2',6'-dichorobenzyloxy)pentanoic acid, t-butyl ester (49 mg) in anisole (0.2 mL) and methylene chloride (2 mL) was treated with TFA (1 mL) and stirred for 30 minutes under a nitrogen atmosphere at room temperature. The resultant solution was concentrated and chased with methylene chloride to give a white solid as the crude product. The crude product was triturated with ether to yield the title product as a white powder (34 mg). MS for C28H31Cl2N3O6 ; MH+ =576/578; (MH)31 =574/576.

WORKUP

后处理

concentrationThe resultant solution was concentrated
customto give a white solid as the crude product
customThe crude product was triturated with ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f1b04023a2cd4524b90a0119fa29b07c
来源数据集: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05877197
来源说明: uspto-grants-1999_03

反应 SMILES

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH3:11])=[C:3]1[C:12]([NH:14][C@H:15]([C:19]([NH:21][CH:22]([C:31](=[O:43])[CH2:32][O:33][CH2:34][C:35]1[C:40]([Cl:41])=[CH:39][CH:38]=[CH:37][C:36]=1[Cl:42])[CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])=[O:20])[CH:16]([CH3:18])[CH3:17])=[O:13].C(O)(C(F)(F)F)=O>C1(OC)C=CC=CC=1.C(Cl)Cl>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH3:11])=[C:3]1[C:12]([NH:14][C@H:15]([C:19]([NH:21][CH:22]([C:31](=[O:43])[CH2:32][O:33][CH2:34][C:35]1[C:40]([Cl:41])=[CH:39][CH:38]=[CH:37][C:36]=1[Cl:42])[CH2:23][C:24]([OH:26])=[O:25])=[O:20])[CH:16]([CH3:18])[CH3:17])=[O:13]