反应详情

To the above Compound (29a) (100 mg, 0.20 mmol) dissolved in 5.0 ml of THF and 2.0 ml of ethyl acetate was added 45 mg of 10% palladium-carbon, and the mixture stirred at room temperature for 3 hours under hydrogen atmosphere. The palladium-carbon was filtered off, and the filtrate concentrated under reduced pressure. The residue was then purified by a silica gel column chromatography (silica gel 5.2 g; ethyl acetate) to give 78 mg (96%) of Compound (30a).

1. filtrationThe palladium-carbon was filtered off
2. concentrationthe filtrate concentrated under reduced pressure
3. customThe residue was then purified by a silica gel column chromatography (silica gel 5.2 g; ethyl acetate)