Hydrochloric Acid → 2-Amino-3-(2-vinylphenyl)propanoic acid
Reaction equation
CS(C(S(C)(=O)=O)=[N:6][CH:7]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH:31]=[CH2:32])[C:8](N1C2CC3C(C)(C)C2(CC3)CS1(=O)=O)=[O:9])(=O)=O.Cl.[O:38]1CCCC1>>[NH2:6][CH:7]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH:31]=[CH2:32])[C:8]([OH:9])=[O:38]Participants
Procedure
For example, the appropriate 2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-3-(2-vinyl-phenyl)-propan-1-one derivative of structure (5) is treated with a suitable acid such as aqueous hydrochloric acid in a suitable organic solvent such as tetrahydrofuran. The reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time ranging from 30 minutes to 20 hours. Evaporation of the solvent followed by treatment with inorganic base such as aqueous lithium hydroxide in a suitable organic solvent, such as tetrahydrofuran. The reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time ranging from 30 minutes to 10 hours. After acidification, the corresponding 2-amino-3-(2-vinyl-phenyl)-propionic acid derivative of structure (6) was isolated by evaporation of solvents.
Workup
- waitThe reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time
- waitranging from 30 minutes to 20 hours
- customEvaporation of the solvent
- waitThe reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time
- waitranging from 30 minutes to 10 hours
Sources & evidence
- ORD record
- ord-35d59221969b412aba2fe7bf3900825c
- Source dataset
- uspto-grants-1999_03
- Patent number
- US05880119
Reaction notes
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