Cesium carbonate → HCID 9848132, compound

HRID 1418322Notes

Reaction equation

HRID 1418322 reaction equation
C(=O)([O-])[O-].[Cs+].[Cs+].[CH3:7][C:8]1[C:9](=[O:15])[NH:10][N:11]=[C:12]([CH3:14])[CH:13]=1.[O:16]1[C:20]2[CH:21]=[CH:22][C:23]([CH:25](Br)[C:26]([NH:28][S:29]([C:32]3[CH:37]=[CH:36][C:35]([CH:38]([CH3:40])[CH3:39])=[CH:34][CH:33]=3)(=[O:31])=[O:30])=[O:27])=[CH:24][C:19]=2[O:18][CH2:17]1>CN(C=O)C>[O:16]1[C:20]2[CH:21]=[CH:22][C:23]([CH:25]([N:10]3[C:9](=[O:15])[C:8]([CH3:7])=[CH:13][C:12]([CH3:14])=[N:11]3)[C:26]([NH:28][S:29]([C:32]3[CH:37]=[CH:36][C:35]([CH:38]([CH3:40])[CH3:39])=[CH:34][CH:33]=3)(=[O:30])=[O:31])=[O:27])=[CH:24][C:19]=2[O:18][CH2:17]1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 193965CetohexazineHCID 15379785HCID 15379785, compound

Product 1

HCID 9848132HCID 9848132, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.3 g of caesium carbonate are added to a solution of 1.55 g of 2,3-dihydro-4,6-dimethylpyridazin-3-one (prepared according to F. H. McMillan et al., J. Am.Chem. Soc. 78, 407 (1956)) and 4.52 g of 2-(1,3-benzodioxol-5-yl)-2-bromo-N-(4-isopropylphenylsulfonyl)acetamide in 100 ml of DMF. The mixture is stirred at room temperature for 2 hours and worked up in the customary manner and 2-(1,3-benzodioxol-5-yl)-2-(2,3-dihydro-4,6-dimethylpyridazin-3-on-2-yl)N-(4-isopropylphenylsulfonyl)acetamide is obtained, m.p. 105°.

Sources & evidence

ORD record
ord-9082dff38d0142078b94c7aee7c9946c
Source dataset
uspto-grants-1999_03
Patent number
US05883090

Reaction notes

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