Triethylamine → HCID 35370593, compound

HRID 1418369Notes

Reaction equation

HRID 1418369 reaction equation
[CH2:1]1[O:10][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[O:3][CH2:2]1.C(N(CC)CC)C.[CH3:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>C(OCC)(=O)C>[CH2:1]1[O:10][C:4]2([CH2:9][CH2:8][N:7]([C:23](=[O:24])[C:22]3[CH:26]=[CH:27][C:19]([CH3:18])=[CH:20][CH:21]=3)[CH2:6][CH2:5]2)[O:3][CH2:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 134054-Methylbenzoyl ChlorideHCID 674351,4-Dioxa-8-azaspiro(4.5)decane

Product 1

HCID 35370593HCID 35370593, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-piperidone ethylene ketal (1.43 g, 10 mimol) and triethylamine (10 mmol, 1.4 ml) was added dropwise a solution of 4-methylbenzoyl chloride (1.55 g, 10 mmol) in ethyl acetate (20 ml) and the mixture stirred for 2 h. The mixture was washed twice with water followed by brine, dried over sodium sulphate and evaporated to give an off-white solid, m.p. 59°-61° C.

Workup

  1. washThe mixture was washed twice with water
  2. dry with materialdried over sodium sulphate
  3. customevaporated
  4. customto give an off-white solid, m.p. 59°-61° C.

Sources & evidence

ORD record
ord-7f1753df29154adab21cb276169ef24a
Source dataset
uspto-grants-1999_03
Patent number
US05883102

Reaction notes

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