Trifluoroacetic acid → HCID 53661008, compound

HRID 1418693Notes

Reaction equation

HRID 1418693 reaction equation
[CH3:1][C:2]1[C:3](=[O:36])[N:4]2[C:16](=[CH:17][C:18]=1[CH:19]([O:22][C:23](=[O:35])[C:24]([NH:27]C(OC(C)(C)C)=O)([CH3:26])[CH3:25])[CH2:20][CH3:21])[C:7]1=[N:8][C:9]3[C:14]([CH:15]=[C:6]1[CH2:5]2)=[CH:13][CH:12]=[CH:11][CH:10]=3.C(C(O)=O)(F)(F)F>O>[NH2:27][C:24]([CH3:25])([CH3:26])[C:23]([O:22][CH:19]([C:18]1[CH:17]=[C:16]2[N:4]([CH2:5][C:6]3[C:7]2=[N:8][C:9]2[C:14]([CH:15]=3)=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:3](=[O:36])[C:2]=1[CH3:1])[CH2:20][CH3:21])=[O:35]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67874023HCID 67874023, compound

Product 1

HCID 53661008HCID 53661008, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared according to the procedure in Example 3B except using (±)-8-methyl-7-[1-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-1-oxopropyl]oxy]propyl]indolizino[1,2-b]quinolin-9(11H)-one. 1H NMR (DMSO-d6) d 8.67 (s, 1H), 8.11 (m, 2H), 7.84 (m, 1H), 7.70 (m, 1H), 7.21 (s, 1H), 5.85 (dd, J=7.9, 5.8 Hz, 1H), 5.25 (s, 2H), 2.24 (s, 3H), 2.1-1.83 (m, 2H), 1.52 (s, 3H), 1.49 (s, 3H), 0.97 (t, J=7.3 Hz, 3H). Anal. Calcd for C23H25N3O3.CF3CO2H.2 H2O: C, 55.45; H, 5.58; N, 7.76. Found: C, 55.85; H, 5.19; N, 7.83.

Sources & evidence

ORD record
ord-347ad6534889412983963529d30ea9cc
Source dataset
uspto-grants-1999_03
Patent number
US05883255

Reaction notes

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