反应详情

15.1 g (100 mmol) of N-benzylethanolamine is dissolved in 50 ml of tetrahydrofuran and mixed with 15 ml of water and 13.8 g (100 mmol) of potassium carbonate. After instillation of 20.5 g (105 mmol) of bromoacetic acid-tert-butyl ester, it is stirred for 6 hours at 65° C. After cooling, it is filtered, concentrated by evaporation in a vacuum and the residue is chromatographed on silica gel with diethyl ether/hexane/triethylamine. The product fractions are concentrated by evaporation in a vacuum and dried.

1. temperatureAfter cooling
2. filtrationit is filtered
3. concentrationconcentrated by evaporation in a vacuum
4. customthe residue is chromatographed on silica gel with diethyl ether/hexane/triethylamine
5. concentrationThe product fractions are concentrated by evaporation in a vacuum
6. customdried