Hydrochloric Acid → HCID 21842306, compound

HRID 1418907Notes

Reaction equation

HRID 1418907 reaction equation
[CH2:1]([N:3]([CH2:6][C:7]1[O:11][C:10]([C:12]2[N:13]=[CH:14][N:15]3[C:21]4[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:20]=4[C:19](=[O:27])[N:18]([CH3:28])[CH2:17][C:16]=23)=[N:9][CH:8]=1)[CH2:4][CH3:5])[CH3:2].[ClH:29]>C(OCC)(=O)C>[ClH:29].[CH2:1]([N:3]([CH2:6][C:7]1[O:11][C:10]([C:12]2[N:13]=[CH:14][N:15]3[C:21]4[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:20]=4[C:19](=[O:27])[N:18]([CH3:28])[CH2:17][C:16]=23)=[N:9][CH:8]=1)[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842266HCID 21842266, compound

Product 1

HCID 21842306HCID 21842306, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.89 g (0.00232 mol) of 3-(5-diethylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]-benzodiazepin-6-one in 50 ml of ethyl acetate was treated with 0.66 ml (0.00244 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1/2 hr. the white suspension was suction filtered. There was obtained 0.94 g (97%) of 3-(5-diethylaminomethyl-oxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as whitish crystals; m.p. 247°-250° (dec.).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-a8edb67150f84ca680b195e8b9f04994
Source dataset
uspto-grants-1999_03
Patent number
US05885986

Reaction notes

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