N-methyl-2-pyrrolidone → N-(1-cyclopropylsulfonylpiperidin-3-yl)-6-[[2-(1-methylpyrazol-4-yl)-4-pyridinyl]oxy]-1,3-benzothiazol-2-amine

HRID 141891Notes

Reaction equation

HRID 141891 reaction equation
[CH3:1][n:2]1[n:3][cH:4][c:5](-[c:7]2[n:8][cH:9][cH:10][c:11]([O:13][c:14]3[cH:15][c:16]4[c:17]([n:18][c:19]([NH:21][CH:22]5[CH2:23][NH:24][CH2:25][CH2:26][CH2:27]5)[s:20]4)[cH:28][cH:29]3)[cH:12]2)[cH:6]1.[CH3:46][N:47]1[CH2:48][CH2:49][CH2:50][C:51]1=[O:52].[CH:30]([N:31]([CH2:32][CH3:33])[CH:34]([CH3:35])[CH3:36])([CH3:37])[CH3:38].[CH:39]1([S:42](=[O:43])(=[O:44])[Cl:45])[CH2:40][CH2:41]1>>[CH3:1][n:2]1[n:3][cH:4][c:5](-[c:7]2[n:8][cH:9][cH:10][c:11]([O:13][c:14]3[cH:15][c:16]4[c:17]([n:18][c:19]([NH:21][CH:22]5[CH2:23][N:24]([S:42]([CH:39]6[CH2:40][CH2:41]6)(=[O:43])=[O:44])[CH2:25][CH2:26][CH2:27]5)[s:20]4)[cH:28][cH:29]3)[cH:12]2)[cH:6]1

Participants

5

Reactant 4

HCID 13387N-methyl-2-pyrrolidoneHCID 81531DiisopropylethylamineHCID 2760919Cyclopropanesulfonyl chlorideHCID 874213196-[[2-(1-methylpyrazol-4-yl)-4-pyridinyl]oxy]-N-piperidin-3-yl-1,3-benzothiazol-2-amine

Product 1

HCID 87421237N-(1-cyclopropylsulfonylpiperidin-3-yl)-6-[[2-(1-methylpyrazol-4-yl)-4-pyridinyl]oxy]-1,3-benzothiazol-2-amine

Sources & evidence

ORD record
ord-aeecf021007e4708ac902373578deb39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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