4-Hydroxybenzaldehyde → HCID 21960195, compound

HRID 1418997Notes

Reaction equation

HRID 1418997 reaction equation
Cl[CH2:2][C:3]1[N:4]([CH3:14])[C:5]2[C:10]([C:11](=[O:13])[N:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>>[CH3:14][N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:11](=[O:13])[N:12]=[C:3]1[CH2:2][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 21960152HCID 21960152, compound

Product 1

HCID 21960195HCID 21960195, compoundYield 65%

Procedure

The title compound (364 mg, 65%) was prepared from 2-chloromethyl-1-methyl-4-oxo-1,4-dihydroquinazoline (416 mg, 2.0 nmmol) and 4-hydroxybenzaldehyde (244 mg, 2.0 mmol) in the presence of K2CO3 (276 mg, 2.0 mmol) as base by a similar procedure to that described in preparation 13.

Workup

  1. customthat described in preparation 13

Sources & evidence

ORD record
ord-3280c2e937024c87bbe0f68343669dba
Source dataset
uspto-grants-1999_03
Patent number
US05885997

Reaction notes

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