HRID1419223

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID136029813

未命名化合物

HCID178479746

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.N=C(N)c1ccc2c(CCC(N)=O)c(OC(=O)c3ccc(NC=NNCCO)cc3)ccc2c1

HCID178478763

未命名化合物

收率 78.3%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

20 Milliliters of 20% hydrous pyridine was added to 1.45 g of 4-[(2-hydroxyethyl)aminoiminomethylamino]benzoic acid.hydrochloride, 1.5 g of 6-amidino-1-(2-carbamoylethyl)-2-naphthol.hydrochloric acid, 1.26 g of DCC and 62.3 mg of DMAP, followed by stirring for 2 hours under cooling with ice and then 24 hours at room temperature. Thereafter, the same procedure as in Example 1 was effected to obtain 1.17 g of the desired product.

WORKUP

后处理

temperatureunder cooling with ice
custom24 hours
customat room temperature

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cc1056b5172b446b83b33b3351fbff5e
来源数据集: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05885990
来源说明: uspto-grants-1999_03

反应 SMILES

[ClH:1].[OH:2][CH2:3][CH2:4][NH:5][N:6]=[CH:7][NH:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=1.[C:18]([C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[C:27]([CH2:31][CH2:32][C:33](=[O:35])[NH2:34])=[C:26](O)[CH:25]=[CH:24]2)(=[NH:20])[NH2:19].Cl.C1CCC(N=C=NC2CCCCC2)CC1>CN(C1C=CN=CC=1)C.N1C=CC=CC=1>[ClH:1].[ClH:1].[OH:2][CH2:3][CH2:4][NH:5][N:6]=[CH:7][NH:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([O:15][C:26]2[CH:25]=[CH:24][C:23]3[C:28](=[CH:29][CH:30]=[C:21]([C:18](=[NH:19])[NH2:20])[CH:22]=3)[C:27]=2[CH2:31][CH2:32][C:33](=[O:35])[NH2:34])=[O:14])=[CH:11][CH:10]=1