反应详情

温度

0 °C

Phosgene (1.14 ml, 20% in toluene) was added dropwise to a solution of N-(3-amino-5-chloro-2-thienylsulfonyl)-N'-isopropylthiourea (0.63 g, 2.0 mmol) and dry triethylamine (0.56 ml, 4.0 mmol) in dry tetrahydrofuran (10 ml) with stirring at 0° C. The mixture was stirred for 1 h at 0° C., and evaporated to dryness. The residue was triturated with water, and the precipitate was isolated by filtration, washed with water and dried affording 0.52 g (93%) of the title compound.

1. stirringThe mixture was stirred for 1 h at 0° C.
2. customevaporated to dryness
3. customThe residue was triturated with water
4. customthe precipitate was isolated by filtration
5. washwashed with water
6. customdried