(1-Isothiocyanatoethyl)benzene → HCID 178462006, compound

HRID 1419744Notes

Reaction equation

HRID 1419744 reaction equation
Cl.[NH2:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH3:13][CH:14]([N:21]=[C:22]=S)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(OCC)(=O)C>[Cl:8][C:6]1[S:5][C:4]2[S:9](=[O:10])(=[O:11])[N:12]=[C:22]([NH:21][C@H:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH3:13])[NH:2][C:3]=2[CH:7]=1

Participants

4

Reactant 2

HCID 20559(1-Isothiocyanatoethyl)benzeneHCID 688206263-Amino-5-chlorothiophene-2-sulfonamide hydrochloride

Product 1

HCID 178462006HCID 178462006, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared from 3-amino-5-chlorothiophene-2-sulfonamide hydrochloride and L-α-methylbenzyl isothiocyanate by a procedure analogous to the procedure described in example 3Bc-d; mp 195°-204° C. (ethyl acetate), 1H-NMR (DMSO-d6): δ 1.46 (d, 3H), 4.95 (m, 1H), 7.1 (s, 1H), 7.2-7.45 (m, 5H), 7.78 (br. s, 1H), 10.85 (s, 1H).

Sources & evidence

ORD record
ord-a3de523cf1a74128a15a36d6b42dcff4
Source dataset
uspto-grants-1999_03
Patent number
US05889002

Reaction notes

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