Ammonia → HCID 178429769, compound

HRID 1419812Notes

Reaction equation

HRID 1419812 reaction equation
[CH3:1][C:2]1([CH:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[H][H].[NH3:17]>[Rh]>[CH3:1][C:2]1([C@@H:8]2[CH2:13][CH2:12][C@H:11]([NH2:17])[CH2:10][CH2:9]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 54040220HCID 54040220, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 178429769HCID 178429769, compound

Reagents, catalysts & solvents 1

HCID 23948RhodiumCatalyst

Procedure

36 g (0.185 mol) of 4-(1-methylcyclohexyl)cyclohexanone were subjected to reductive amination in 210 ml of ammonia-saturated methanol in the presence of 3 g of rhodium (5% on charcoal) at 50° C. and 50 bar hydrogen pressure.

Sources & evidence

ORD record
ord-1d4a242e7bd44363875f10758ad4e2ef
Source dataset
uspto-grants-1999_03
Patent number
US05889012

Reaction notes

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