Hydrochloric Acid → 2-(2-Methylthioethoxy)aniline

HRID 1419890노트

반응식

HRID 1419890 반응식
O.O.[Sn](Cl)(Cl)(Cl)Cl.[CH3:8][S:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-])=O.Cl.[OH-].[Na+]>C(O)C>[CH3:8][S:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH2:19]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 539101632-(2-Methylthioethoxy)nitrobenzeneHCID 85782573Tin tetrachloride dihydrate

생성물 1

HCID 542131632-(2-Methylthioethoxy)aniline

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Tin chloride dihydrate (57.9 g, 0.26 mole) in ethyl alcohol (90 ml) was added to a mixture of 2-(2-methylthioethoxy)nitrobenzene (18.1g, 0.085 mole), conc. HCl (72.4 ml) and ethyl alcohol (36 ml). The reaction mixture was stirred for 24 h at room temperature. Sodium hydroxide (6M, 270 ml) was added to the reaction mixture. Extraction with methylene chloride (3×400 ml) gave after drying the organic layer over sodium sulfate and evaporation of the solvent 14.8 g (95%) of the title compound.

후처리

  1. extractionExtraction with methylene chloride (3×400 ml)
  2. customgave
  3. customafter drying the organic layer
  4. customover sodium sulfate and evaporation of the solvent 14.8 g (95%) of the title compound

출처 및 근거

ORD 기록
ord-ca97d4e11d6543e59d3301fc98a1da16
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05889021

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