Benzyl Bromide → HCID 69471538, compound

HRID 1420132Notes

Reaction equation

HRID 1420132 reaction equation
[F:1][CH2:2][C:3]([NH2:5])=[S:4].[CH2:6]([Br:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl.CCOCC>[BrH:13].[CH2:6]([S:4][C:3](=[NH:5])[CH2:2][F:1])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 7498Benzyl BromideHCID 16737206HCID 16737206, compound

Product 1

HCID 69471538HCID 69471538, compoundYield 54%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

Fluorothioacetamide (3.39 g) and benzyl bromide (6.23 g) were refluxed in chloroform (40 ml), under nitrogen, for 16 h. After cooling, the mixture was diluted with ether (200 ml) and the resulting orange solid filtered off. The solid was washed with more ether and dried over P2O5 in vacuo to give 5.19 g of the desired product.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting orange solid filtered off
  3. washThe solid was washed with more ether
  4. dry with materialdried over P2O5 in vacuo

Sources & evidence

ORD record
ord-93a754e113f9425abbc9ad40dd8b8ff7
Source dataset
uspto-grants-1999_03
Patent number
US05889056

Reaction notes

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