2-Chloropropane → HCID 131721833, compound

HRID 1420463Notes

Reaction equation

HRID 1420463 reaction equation
[CH:1]([Cl:4])([CH3:3])[CH3:2].[CH2:5]([OH:81])[C@H:6]1[O:11][C@@H:10]2[O:12][C@H:13]3[C@H:18]([OH:19])[C@@H:17]([OH:20])[C@@H:16]([O:21][C@H:22]4[C@H:27]([OH:28])[C@@H:26]([OH:29])[C@@H:25]([O:30][C@H:31]5[C@H:36]([OH:37])[C@@H:35]([OH:38])[C@@H:34]([O:39][C@H:40]6[C@H:45]([OH:46])[C@@H:44]([OH:47])[C@@H:43]([O:48][C@H:49]7[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]8[C@H:64]([OH:65])[C@@H:63]([OH:66])[C@@H:61]([O:62][C@H:7]1[C@H:8]([OH:80])[C@H:9]2[OH:79])[O:60][C@@H:59]8[CH2:67][OH:68])[O:51][C@@H:50]7[CH2:69][OH:70])[O:42][C@@H:41]6[CH2:71][OH:72])[O:33][C@@H:32]5[CH2:73][OH:74])[O:24][C@@H:23]4[CH2:75][OH:76])[O:15][C@@H:14]3[CH2:77][OH:78]>>[CH2:71]([OH:72])[C@H:41]1[O:42][C@@H:43]2[O:48][C@H:49]3[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]4[C@H:64]([OH:65])[C@@H:63]([OH:66])[C@@H:61]([O:62][C@H:7]5[C@H:8]([OH:80])[C@@H:9]([OH:79])[C@@H:10]([O:12][C@H:13]6[C@H:18]([OH:19])[C@@H:17]([OH:20])[C@@H:16]([O:21][C@H:22]7[C@H:27]([OH:28])[C@@H:26]([OH:29])[C@@H:25]([O:30][C@H:31]8[C@H:36]([OH:37])[C@@H:35]([OH:38])[C@@H:34]([O:39][C@H:40]1[C@H:45]([OH:46])[C@H:44]2[OH:47])[O:33][C@@H:32]8[CH2:73][OH:74])[O:24][C@@H:23]7[CH2:75][OH:76])[O:15][C@@H:14]6[CH2:77][OH:78])[O:11][C@@H:6]5[CH2:5][OH:81])[O:60][C@@H:59]4[CH2:67][OH:68])[O:51][C@@H:50]3[CH2:69][OH:70].[CH:1]([Cl:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 63612-ChloropropaneHCID 444041beta-Cyclodextrin

Product 1

HCID 131721833HCID 131721833, compound

Procedure

100 ml of saturated β-cyclodextrin solution (1.8%) were cooled to 10° C. and mixed with 3 ml of isopropylchloride. The resulting difficultly soluble complex was precipitated with constant stirring in the ultrasonic bath. The deposit was obtained in crystalline form through freeze-drying and filtering. Isopropylchloride content according to GC calculation: 0.5%.

Workup

  1. customThe resulting difficultly soluble complex was precipitated
  2. customThe deposit was obtained in crystalline form
  3. customthrough freeze-drying
  4. filtrationfiltering

Sources & evidence

ORD record
ord-0878944c87504ce08b1125dba864f3fd
Source dataset
uspto-grants-2000_06
Patent number
US06071496

Reaction notes

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