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A solution containing 13 g of 1-(2,5-dichlorobenzyl)-4-ethoxycarbonylpiperazine in 35 mL of 37% HCl was stirred for 40 h at reflux. Subsequently, 30 mL of water and 30 mL of EtOAc were added at room temperature, adjusting the pH to 11 via addition of 35% NaOH. The organic phase, which was dried on anhydrous sodium sulphate, was evaporated to dryness under vacuum. The crude was purified via flash chromatography (CHCl3 --MeOH 7:3) giving 4.46 g (50%) of the title compound.

1. temperatureat reflux
2. dry with materialThe organic phase, which was dried on anhydrous sodium sulphate
3. customwas evaporated to dryness under vacuum
4. customThe crude was purified via flash chromatography (CHCl3 --MeOH 7:3)