Hydrochloric Acid → HCID 18782298, compound

HRID 1420632Notes

Reaction equation

HRID 1420632 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH2:9])=[CH:5][CH:6]=[CH:7][CH:8]=1.[F:10][C:11]([F:19])([F:18])[C:12](=[O:17])[CH2:13][C:14](=O)[CH3:15].Cl>C(OCC)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[C:14]([CH3:15])[CH2:13][C:12](=[O:17])[C:11]([F:19])([F:18])[F:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 70002-MethoxyanilineHCID 739431,1,1-Trifluoro-2,4-pentanedione

Product 1

HCID 18782298HCID 18782298, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
102.5 °C

Procedure

A mixture of 28.4 g (0.23 mol) of o-anisidine and 43.18 g (0.28 mol) of 1,1,1-trifluoro-2,4-pentanedione is heated at 100-105° C. for one hour and then cooled and the reaction medium is taken up with ethyl ether. 10 ml of 1 N hydrochloric acid are added. The mixture is filtered to remove the insoluble product, and the filtrate is concentrated under reduced pressure to give the expected product in the form of a beige solid (yield=98%).

Workup

  1. temperaturecooled
  2. filtrationThe mixture is filtered
  3. customto remove the insoluble product
  4. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-048ac87bfb9e442b950e7bfe53f009ac
Source dataset
uspto-grants-2000_06
Patent number
US06071917

Reaction notes

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