Water → HCID 18782678, compound

Temperature

80 °C

2-bromo-4-(trifluoroacetamido)methylanisole (5 g, 16 mmol) was suspended in carbon tetrachloride (125 ml). Triphenylphosphine (8 g, 30.5 mmol) was added and the mixture stirred at 80° C. for 16 hours. Solvent was removed in vacuo and the residue poured into hexane (100 ml) and stirred at reflux for 30 minutes. The suspension was filtered through Hyflo™ and the filtrate concentrated to an oil. The oil in N,N-dimethylformamide (15 ml) was added to a stirred solution of sodium azide (1 g, 15 mmol) in N,N-dimethylformamide at 0° C. The mixture was stirred at ambient temperature for 2 hours then poured into water (200 ml) and extracted with ethyl acetate (2×100 ml). The combined organics were washed with water (3×200 ml), dried over sodium sulfate and the solvent was removed in vacuo leaving a yellow oil. Chromatography on silica gel, eluting with 10-50% ethyl acetate in hexane, gave the title compound as a yellow oil (230 mg, 5%, δH (360MHz, CDCl3) 4.90 (1H, d, J 7.6Hz, NCHAHBAr), 4.95 (1H, d, J 7.6 Hz, NCHAHBAr), 7.00 (1H, d, J 8.6Hz, 6-H), 7.52 (1H, dd, J 2.2, 8.5Hz, 5-H), 7.80 (1H, d, 2.2Hz, 3-H); m/z (ES+) 337, 339 ([M+H]+).

1. customSolvent was removed in vacuo
2. additionthe residue poured into hexane (100 ml)
3. stirringstirred
4. temperatureat reflux for 30 minutes
5. filtrationThe suspension was filtered through Hyflo™
6. concentrationthe filtrate concentrated to an oil
7. stirringThe mixture was stirred at ambient temperature for 2 hours
8. extractionextracted with ethyl acetate (2×100 ml)
9. washThe combined organics were washed with water (3×200 ml)
10. dry with materialdried over sodium sulfate
11. customthe solvent was removed in vacuo
12. customleaving a yellow oil
13. washChromatography on silica gel, eluting with 10-50% ethyl acetate in hexane

ORD record

ord-b1269d73fe2e400cb1422909a5d9c43a

Source dataset

uspto-grants-2000_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06071928