Nitromethane → HCID 9927343, compound

HRID 1420772Notes

Reaction equation

HRID 1420772 reaction equation
Br[C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1.[OH-].[K+].[N+:24](C)([O-:26])=[O:25]>>[N+:24]([C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1)([O-:26])=[O:25]

Participants

4

Reactant 3

HCID 6375NitromethaneHCID 14797Potassium HydroxideHCID 9906877HCID 9906877, compound

Product 1

HCID 9927343HCID 9927343, compound

Procedure

A solution of 1 mmol of the compound obtained in Example 12 in 50 ml of nitromethane is stirred for 12 hours at ambient temperature and the reaction mixture is then poured into a 1M potassium hydroxide solution. After extracting with dichloromethane, the organic phases are dried over sodium sulphate, filtered and concentrated under reduced pressure. Chromatography on silica gel (chloroform) allows the expected product to be isolated.

Workup

  1. extractionAfter extracting with dichloromethane
  2. dry with materialthe organic phases are dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customto be isolated

Sources & evidence

ORD record
ord-725fbe83ab464311998c3e82eca88d25
Source dataset
uspto-grants-2000_06
Patent number
US06071945

Reaction notes

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