Hydrogen Bromide → HCID 12128597, compound

HRID 1420776Notes

Reaction equation

HRID 1420776 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:25]3[N:24]4[C:20](=[CH:21][CH:22]=[CH:23]4)[C:19](=[O:26])[C:18]=3[S:17][CH:16]=2)=[CH:11][C:10]=1[O:27][CH3:28])C1C=CC=CC=1.Br.O>C(O)(=O)C>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:25]3[N:24]4[C:20](=[CH:21][CH:22]=[CH:23]4)[C:19](=[O:26])[C:18]=3[S:17][CH:16]=2)=[CH:11][C:10]=1[O:27][CH3:28]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 12128596HCID 12128596, compound

Product 1

HCID 12128597HCID 12128597, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1mmol of the compound of Example 23 dissolved in an excess of hydrobromic acid in 33% acetic acid is stirred for 30 minutes at ambient temperature. After adding 100 ml of water, a precipitate is formed, which is filtered off and then dried. Chromatography on silica gel (ethyl acetate/hexane:1/2) allows the expected product to be isolated.

Workup

  1. customa precipitate is formed
  2. filtrationwhich is filtered off
  3. customdried
  4. customto be isolated

Sources & evidence

ORD record
ord-772ea38848d24e82a1a0a3b17590c625
Source dataset
uspto-grants-2000_06
Patent number
US06071945

Reaction notes

Loading…