反应详情

温度

110 °C

To a solution of 4-benzyloxyphenol (5 g) and 2,2,2-trifluoroethyl-p-toluenesulphonate (5 g) in dimethylformamide (50 ml) was added sodium hydride (60% dispersion in oil, 2.3 g) and the solution heated to 110° C. for 16 h. The mixture was cooled, diluted with water and the product extracted into ethyl acetate. The organic phase was washed with water, brine and dried (MgSO4). The solvent was remove in vacuo and the residue chromatographed on silica gel (eluting with 10% diethyl ether/hexane) to give the the title compound as a solid, m.p. 72-74° C.

1. temperatureThe mixture was cooled
2. extractionthe product extracted into ethyl acetate
3. washThe organic phase was washed with water, brine
4. dry with materialdried (MgSO4)
5. customThe solvent was remove in vacuo
6. customthe residue chromatographed on silica gel (eluting with 10% diethyl ether/hexane)