Ammonia → HCID 5327661, compound

HRID 1421142Notes

Reaction equation

HRID 1421142 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:27])[O:13][C:14](=O)[C:15]=2[C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)=[CH:3]1.[NH3:28]>CN(C=O)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:27])[NH:28][C:14](=[O:13])[C:15]=2[C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)=[CH:3]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14525670HCID 14525670, compound

Product 1

HCID 5327661HCID 5327661, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

56 mg of 3-(1-methyl-3-indolyl)-4-(1-naphthyl)furan-2,5-dione were treated with 5 ml of DMF and 5 ml of 33% aqueous ammonia and the mixture was heated at 130° C. for 5 hours. The formed precipitate was filtered off, washed with water and dried to give 53 mg of 3-(1-methyl-3-indolyl)-4-(1-naphthyl)-1H-pyrrole-2,5-dione, m.p. 258°-260° C.

Workup

  1. filtrationThe formed precipitate was filtered off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-a277174e14674a00947626d65525e760
Source dataset
uspto-grants-2000_06
Patent number
USRE036736

Reaction notes

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