Hydrochloric Acid → HCID 86755469, compound

HRID 1421635Notes

Reaction equation

HRID 1421635 reaction equation
C[O:2][C:3](=[O:17])[C@H:4]([CH2:12][C:13]([O:15]C)=[O:14])[NH:5][CH2:6][CH2:7][C:8]([CH3:11])([CH3:10])[CH3:9].[ClH:18]>>[ClH:18].[CH2:6]([NH:5][C@H:4]([C:3]([OH:17])=[O:2])[CH2:12][C:13]([OH:15])=[O:14])[CH2:7][C:8]([CH3:11])([CH3:10])[CH3:9]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 53751206HCID 53751206, compound

Product 1

HCID 86755469HCID 86755469, compoundYield 91%

Procedure

A mixture of N-neohexyl-L-aspartic acid dimethyl ester (15 g, 0.061 mol) in 1N hydrochloric acid (350 mL) was heated at reflux for 4 hours to form a clear solution. The mixture was freeze dried to give N-neohexyl-L-aspartic acid hydrochloride as a white solid (14 g, 91%), M.P. 133-138° C., [α]D +14.69 (c=1, water). Anal. Calc'd. for C10H19NO4 --HCl; C, 47.52; H, 7.92; N, 5.54; Cl, 14.05. Found: C, 47.84; H, 8.14; N, 5.31; Cl, 13.08.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours
  3. customto form a clear solution
  4. customdried

Sources & evidence

ORD record
ord-db8ad0cc5c2148fea6bdec04f5abf56b
Source dataset
uspto-grants-2000_06
Patent number
US06077962

Reaction notes

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