Potassium Carbonate → HCID 18779695, compound

HRID 1421702Notes

Reaction equation

HRID 1421702 reaction equation
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][CH:3]=1.[C:9]([O-:12])([O-])=O.[K+].[K+]>[Cu]>[OH:12][CH2:9][C:3]1[CH:4]=[CH:5][C:6]([N:7]2[C:2]([CH3:1])=[CH:3][CH:4]=[CH:5][C:6]2=[O:8])=[N:7][CH:2]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 767726-Methylpyridin-2-ol

Product 1

HCID 18779695HCID 18779695, compound

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

2-bromo(5-hydroxymethyl)pyridine (3.00 g, 15.95 mmol), 6-methylpyridone (2.08 g, 19.14 mmol), Copper (2.64, 19.14 mmol) and K2CO3 (0.635 g, 10.0 mmol) were heated at 140° C. for 3 hrs. Added CHC13 to reaction when still warm and let stirred overnight. Filterred the mixture through a frit, concentrated in vacuo and the residue was chromatographed (silica gel, 0-4% MeOH-EtOAc solution). Obtained the title compound as a brown oil.

Workup

  1. customAdded CHC13 to reaction when
  2. temperaturestill warm
  3. concentrationconcentrated in vacuo
  4. customthe residue was chromatographed (silica gel, 0-4% MeOH-EtOAc solution)

Sources & evidence

ORD record
ord-0e5df9b4c1de459eb93200da892be450
Source dataset
uspto-grants-2000_06
Patent number
US06077853

Reaction notes

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