HCID 131721862, compound → HCID 86755472, compound

HRID 1421858Notes

Reaction equation

HRID 1421858 reaction equation
[CH3:1][C@@:2]12[C:18](=[O:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][NH:22][S:23]([O-:26])(=[O:25])=[O:24].B.[Na]>O1CCCC1.CO>[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][NH:22][S:23](=[O:25])(=[O:24])[O-:26]

Participants

5

Reactant 2

HCID 131721862HCID 131721862, compoundHCID 178418435HCID 178418435, compound

Product 1

HCID 86755472HCID 86755472, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Estrone-(N-methyl)amidosulphonate (1 g) is reduced with sodium boron hydride (624.2 mg) in a mixture of tetrahydrofurane (20 ml) and methanol (20 ml). The crude product, following work-up, is recrystallised from acetone/n-hexane to give the title compound.

Workup

  1. customis recrystallised from acetone/n-hexane

Sources & evidence

ORD record
ord-546fd987d56748a0a134d63717a02bf3
Source dataset
uspto-grants-2000_06
Patent number
US06080735

Reaction notes

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