反应详情

3-(Benzhydrylidene-amino)-3-pyridin-4-ylmethyl-dihydro-furan-2-one (1.67 g, 4.69 mMol) was dissolved in a solution of 1 N HCl (20 mL) in THF (50 mL). The mixture was stirred for 1 hour at ambient temperature after which time it was partitioned between ethyl ether (Et2O) and water. The water layer was washed again with Et2O and then adjusted to pH 8 with NaHCO3. The aqueous layer was then extracted with CH2Cl2. The CH2Cl2 layer was dried over Na2SO4, filtered and concentrated under vacuum to give 630 mg of the titled compound as an oil.

1. customwas partitioned between ethyl ether (Et2O) and water
2. washThe water layer was washed again with Et2O
3. extractionThe aqueous layer was then extracted with CH2Cl2
4. dry with materialThe CH2Cl2 layer was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under vacuum