Benzaldehyde → HCID 54273126, compound

HRID 1422036Notes

Reaction equation

HRID 1422036 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[CH:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.Cl.CO>O>[C:14]1([CH:13]=[C:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([OH:1])[CH:3]=3)[C:8]2=[O:12])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 887MethanolHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 54273126HCID 54273126, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and benzaldehyde 0.42 ml were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for two hours and cooled to room temperature, and water 400 ml was added. The precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for six hours under reduced pressure to obtain the desired compound 0.756 g.

Workup

  1. temperaturethe mixture was refluxed for two hours
  2. filtrationThe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for six hours under reduced pressure

Sources & evidence

ORD record
ord-cfbd6eb0d9844c22b19aa063fdd1c3f7
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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