3-Hydroxybenzaldehyde → HCID 54391173, compound

HRID 1422037Notes

Reaction equation

HRID 1422037 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[OH:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH:17]=O.Cl.CO>O>[OH:13][C:14]1[CH:15]=[C:16]([CH:17]=[C:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([OH:1])[CH:3]=3)[C:8]2=[O:12])[CH:19]=[CH:20][CH:21]=1

Participants

6

Reactant 4

HCID 1013-HydroxybenzaldehydeHCID 313Hydrochloric AcidHCID 887MethanolHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 54391173HCID 54391173, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and 3-hydroxybenzaldehyde 0.903 g were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for one hour and cooled to room temperature, and water 400 ml was added. The precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for six hours under reduced pressure to obtain the desired compound 0.92 g.

Workup

  1. temperaturethe mixture was refluxed for one hour
  2. filtrationThe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for six hours under reduced pressure

Sources & evidence

ORD record
ord-979d4b79335c47d7a19621fce1e1dcf4
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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