4-Hydroxybenzaldehyde → HCID 54005619, compound

HRID 1422038Notes

Reaction equation

HRID 1422038 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[OH:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1.Cl.CO>O>[OH:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[C:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([OH:1])[CH:3]=3)[C:8]2=[O:12])=[CH:16][CH:15]=1

Participants

6

Reactant 4

HCID 1264-HydroxybenzaldehydeHCID 313Hydrochloric AcidHCID 887MethanolHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 54005619HCID 54005619, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and 4-hydroxybenzaldehyde 0.903 g were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for one hour and cooled to room temperature, and water 200 ml was added and allowed to stand for one hour. The precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for four hours under reduced pressure to obtain the desired compound 0.941 g.

Workup

  1. temperaturethe mixture was refluxed for one hour
  2. filtrationThe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for four hours under reduced pressure

Sources & evidence

ORD record
ord-1b0c78a6fca347ae8d4d08d4496f06cd
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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