Hydrochloric Acid → HCID 53675108, compound

HRID 1422042Notes

Reaction equation

HRID 1422042 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1.Cl.CO>O>[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[C:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([OH:1])[CH:3]=3)[C:8]2=[O:12])=[CH:16][CH:15]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 707414-BromobenzaldehydeHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 53675108HCID 53675108, compoundYield 35.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and 4-bromobenzaldehyde 1.37 g were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for one hour and cooled to room temperature, and water 250 ml was added. The precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for four hours under reduced pressure to obtain the desired compound 0.72 g.

Workup

  1. temperaturethe mixture was refluxed for one hour
  2. filtrationThe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for four hours under reduced pressure

Sources & evidence

ORD record
ord-c41d199d45394a85ad98517c6a666c40
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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