Lithium hydroxide, monohydrate → HCID 18706397, compound

HRID 1422225Notes

Reaction equation

HRID 1422225 reaction equation
C([O:3][C:4](=[O:21])[C:5]([S:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[O:6])C.O.[OH-].[Li+]>O1CCCC1.O>[Br:19][C:17]1[CH:16]=[C:15]2[C:10]([NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[C:9]([CH2:8][S:7][C:5](=[O:6])[C:4]([OH:21])=[O:3])[CH:18]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 86755474HCID 86755474, compound

Product 1

HCID 18706397HCID 18706397, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

500 mg (1.34 mmol) of 7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethylsulfanylacetic acid ethyl ester (Example 18) are suspended in 20 ml of tetrahydrofuran and 10 ml of water, and 225 mg (4 equiv.) of lithium hydroxide hydrate are added. The mixture is stirred at 20° C. for 48 hours. The tetrahydrofuran is concentrated by evaporation, 60 ml of water are added and the solution is acidified with 1 N hydrochloric acid. The solid is filtered off, washed with water and dried.

Workup

  1. concentrationThe tetrahydrofuran is concentrated by evaporation, 60 ml of water
  2. additionare added
  3. filtrationThe solid is filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-47cfb5837d8d4fdb906f857fea5a6755
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

Loading…