Triethylamine → HCID 18706628, compound

HRID 1422241Notes

Reaction equation

HRID 1422241 reaction equation
[Br:1][CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18]C)[C:7]([O:16]C)=[N:8]2.[CH3:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C(N(CC)CC)C>>[BrH:1].[O:16]=[C:7]1[C:6](=[O:18])[NH:5][C:4]2[C:9](=[CH:10][C:11]([N+:13]([O-:15])=[O:14])=[CH:12][C:3]=2[CH2:2][N:24]2[CH2:25][CH2:26][CH:21]([CH3:20])[CH2:22][CH2:23]2)[NH:8]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 693814-MethylpiperidineHCID 232979835-Bromomethyl-7-nitro-2,3-dimethoxyquinoxaline

Product 1

HCID 18706628HCID 18706628, compound

Procedure

100 mg (0.304 mmol) of 5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline, 0.04 ml (1.1 equiv.) of 4-methyl-piperidine and 0.05 ml (1.2 equiv.) of triethylamine are stirred at reflux for 20 hours. The mixture is concentrated by evaporation and the residue is extracted with ethyl acetate and a 5% sodium carbonate solution. The combined organic phases are dried over magnesium sulfate and concentrated by evaporation.

Workup

  1. temperatureat reflux for 20 hours
  2. concentrationThe mixture is concentrated by evaporation
  3. extractionthe residue is extracted with ethyl acetate
  4. dry with materialThe combined organic phases are dried over magnesium sulfate
  5. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-0a746e03a05b454e94163fd2d4a2afd2
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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