Sodium Bicarbonate → HCID 11538160, compound

HRID 1422310Notes

Reaction equation

HRID 1422310 reaction equation
O1CCOC1C[CH2:7][CH2:8][CH2:9][C:10]1[N:11]=[CH:12][N:13]([C:15]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=1.[C:34](=[O:37])([O-])O.[Na+]>CC(C)=O.Cl>[C:28]1([C:15]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[N:13]2[CH:14]=[C:10]([CH2:9][CH2:8][CH2:7][CH:34]=[O:37])[N:11]=[CH:12]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 18314053HCID 18314053, compound

Product 1

HCID 11538160HCID 11538160, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolvent

Procedure

A suspension of the product from step b (19.8 g, 46.6 mmol) in a mixture of acetone (300 ml) and 2M hydrochloric acid (50 ml) was stirred at room temperature for 20 h. The mixture was neutralised with sodium hydrogen carbonate, filtered and the filtrate extracted with dichloromethane (3×100 ml). The combined extracts were dried over magnesium sulfate, filtered and evaporated to give the product as a colourless oil (16.1 g, 91%).

Workup

  1. filtrationfiltered
  2. extractionthe filtrate extracted with dichloromethane (3×100 ml)
  3. dry with materialThe combined extracts were dried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-3d45d53d7b3041ca9e74aa391d7550ac
Source dataset
uspto-grants-2000_06
Patent number
US06080871

Reaction notes

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