反应详情

To a solution of 3-bromo-N-methyl-5-nitro-benzamide (0.6 g) in DCM (15 ml) at −15° C. was added triflic anhydride (0.6 ml) and the reaction stirred for 30 min. Sodium azide (226 mg) was added and the reaction allowed to warm to room temperature and stirred further overnight. NaHCO3(aq) was added to neutralise the reaction and the mixture extracted into EtOAc. The organic layer was separated, dried and concentrated in vacuum and the residue purified by flash chromatography (9:1 to 2:8 cyclohexane:EtOAc) to give the title compound (290 mg). Rf=0.51 (3:2 cyclohexane:EtOAc).

1. stirringstirred further overnight
2. customthe reaction
3. extractionthe mixture extracted into EtOAc
4. customThe organic layer was separated
5. customdried
6. concentrationconcentrated in vacuum
7. customthe residue purified by flash chromatography (9:1 to 2:8 cyclohexane:EtOAc)