反应详情

1-isobutyl-6-(4-methoxybenzyl)-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (106 mg, 0.3 mmol) and hexachloro ethane (368 mg, 1.55 mmol) are dissolved in anhydrous THF, and then 1.0M LiHMDS in THF (0.6 mL, 0.6 mmol) is added dropwise. The reaction mixture is stirred at room temperature for an hour, and then quenched with saturated ammonium chloride aqueous solution. The mixture is purified by silica-gel column chromatography to give 60 mg of pure product (yield: 51%). MS (ESI) m/z 376.1 [M+H]+.

1. customquenched with saturated ammonium chloride aqueous solution
2. customThe mixture is purified by silica-gel column chromatography