HCID 68345601, compound → HCID 68345602, compound

HRID 1423020Notes

Reaction equation

HRID 1423020 reaction equation
C([O:3][C:4]([C:6]1[N:11]=[N:10][CH:9]=[C:8]2[N:12]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[N:13]=[CH:14][C:7]=12)=[O:5])C>CCOC(C)=O>[F:21][C:18]1[CH:19]=[CH:20][C:15]([N:12]2[C:8]3=[CH:9][N:10]=[N:11][C:6]([C:4]([OH:5])=[O:3])=[C:7]3[CH:14]=[N:13]2)=[CH:16][CH:17]=1

Participants

3

Reactant 1

HCID 68345601HCID 68345601, compound

Product 1

HCID 68345602HCID 68345602, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title product is prepared from 1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyridazine-4-carboxylic acid ethyl ester (520 mg, 1.82 mmol) according to the procedure described in Example 1, with the exception that the reaction progress is monitored for the disappearance of the starting material by TLC (EtOAc:hexanes; 1:1) prior to work up.

Sources & evidence

ORD record
ord-f522d23b5eb44531a7c2b8a473a06144
Source dataset
uspto-grants-2015_01
Patent number
US08927550B2

Reaction notes

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