反应详情

To a solution of 2-bromo-thiazole-5-carboxaldehyde (1.00 g, 5.21 mmol) in THF (10 mL) is added a 3 M solution of ethylmagnesium bromide (5.00 mL, 15.0 mmol) in diethyl ether. After 18 hours, the reaction is poured into saturated aqueous ammonium chloride (100 mL) containing crushed ice and diluted with EtOAc (100 mL). The organic phase is separated, washed with saturated aqueous sodium bicarbonate solution (100 mL), dried over sodium sulfate, filtered and concentrated. The compound is purified by silica gel chromatography eluting using a gradient of 0-100% EtOAc in hexanes to provide 1-(2-bromo-thiazol-5-yl)-propan-1-ol.

1. additioncontaining
2. customcrushed ice
3. customThe organic phase is separated
4. washwashed with saturated aqueous sodium bicarbonate solution (100 mL)
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customThe compound is purified by silica gel chromatography
9. washeluting