Hydrochloric Acid → HCID 66727689, compound

HRID 1423058Notes

Reaction equation

HRID 1423058 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C@@H:8]([NH2:11])[CH2:9][CH3:10])[CH:3]=1.C(=O)(O)[O-].[Na+].[ClH:17]>>[ClH:17].[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C@@H:8]([NH2:11])[CH2:9][CH3:10])[CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 59278476HCID 59278476, compound

Product 1

HCID 66727689HCID 66727689, compound

Procedure

A mixture of (S)-1-(4-bromopyridin-2-yl)-propylamine (0.600 g, 1.88 mmol) in 3 N aqueous HCl is stirred for 16 hours. The mixture is then added to a solution of saturated aqueous sodium bicarbonate (15 mL) and extracted with EtOAc (5×15 mL). The combined organic layers are dried over sodium sulfate, filtered and concentrated in vacuo to afford the title compound which is used without purification.

Workup

  1. extractionextracted with EtOAc (5×15 mL)
  2. dry with materialThe combined organic layers are dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6d0e4efa93054fe1b5bccb118450cbe5
Source dataset
uspto-grants-2015_01
Patent number
US08927550B2

Reaction notes

Loading…