Hydrochloric Acid → HCID 87126777, compound

HRID 1423062Notes

Reaction equation

HRID 1423062 reaction equation
[Br:1][C:2]1[N:7]=[CH:6][C:5]([C@@H](NS(C(C)(C)C)=O)CC)=[CH:4][CH:3]=1.Cl.[O:19]1[CH2:24][CH2:23]OCC1.[CH3:25][CH2:26]OCC>CO>[Br:1][C:2]1[N:7]=[CH:6][C:5]([CH:24]([OH:19])[CH2:23][CH2:25][CH3:26])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 312751,4-DioxaneHCID 86640810HCID 86640810, compound

Product 1

HCID 87126777HCID 87126777, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 2-methyl-propane-2-sulfinic acid [(S)-1-(6-bromopyridin-3-yl)-propyl]-amide (5.35 g, 16.8 mmol) in methanol (25 mL) is added a solution of 4 N HCl in dioxane (10 mL, 40 mmol). After 2 hour, the mixture is concentrated to near dryness to afford a white solid. The solid is diluted with ether and collected by filtration to afford the title compound.

Workup

  1. concentrationthe mixture is concentrated
  2. customto afford a white solid
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-3fb2aff5d5d346b0b898561f7c89857f
Source dataset
uspto-grants-2015_01
Patent number
US08927550B2

Reaction notes

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